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Nitrazepam, sold under the brand name Mogadon among others, is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as amnestic (inducing forgetfulness), anticonvulsant, and skeletal muscle relaxant effects.
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Buy Nitrazepam 5mg. Nitrazepam, sold under the brand name Mogadon among others, is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as amnestic (inducing forgetfulness), anticonvulsant, and skeletal muscle relaxant effects.
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It has been found to be more effective than clonazepam in the treatment of West syndrome, which is an age-dependent epilepsy, affecting the very young. , drowsiness, hypotonia, and most significantly tolerance to anti-seizure effects typically develop with long-term treatment, generally limiting Nitrazepam to acute seizure management
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More common side effects may include: Central nervous system depression,
including somnolence, dizziness, depressed mood, fatigue, ataxia,
hangover feeling in the morning, slurred speech, decreased physical performance,
double vision, and inattention have been reported.
half-life of 15–38 hours (mean elimination half-life 26 hours).
of nitrazepam such as sleepiness, impaired psychomotor and
cognitive functions may persist into the next day,
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Less common side effects may include: Hypotension, faintness,
palpitation, rash or pruritus, gastrointestinal disturbances, and
changes in libido are less common. Very infrequently,
paradoxical reactions may occur, for example, excitement, stimulation,
hallucinations, hyperactivity, and insomnia. Severe liver toxicity has also been reported.
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Nitrazepam therapy, compared with other drug therapies, increases risk of death when used for intractable epilepsy in an analysis of 302 patients. The risk of death from nitrazepam therapy may be greater in younger patients (children below 3.4 years in the study) with intractable epilepsy. In older children (above 3.4 years), the tendency appears to be reversed in this study. Nitrazepam may cause sudden death in children. It can cause swallowing incoordination, high-peaked esophageal peristalsis, bronchospasm, delayed cricopharyngeal relaxation, and severe respiratory distress necessitating ventilatory support in children. Nitrazepam may promote the development of parasympathetic overactivity or vagotonia, leading to potentially fatal respiratory distress in children.
This activation can lead to the generation of free radicals and oxidation of thiol, as well as covalent binding with endogenous macromolecules; this results, then, in oxidation of cellular components or inhibition of normal cellular function.
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